A team of biologists and chemists is closing in on bringing non-living matter to life.

It's not as Frankensteinian as it sounds. Instead, a lab led by Jack Szostak, a molecular biologist at Harvard Medical School, is building simple cell models that can almost be called life.

Szostak's protocells are built from fatty molecules that can trap bits of nucleic acids that contain the source code for replication. Combined with a process that harnesses external energy from the sun or chemical reactions, they could form a self-replicating, evolving system that satisfies the conditions of life, but isn't anything like life on earth now, but might represent life as it began or could exist elsewhere in the universe. 

While his latest work remains unpublished, Szostak described preliminary new success in getting protocells with genetic information inside them to replicate at the XV International Conference on the Origin of Life in Florence, Italy, last week. The replication isn't wholly autonomous, so it's not quite artificial life yet, but it is as close as anyone has ever come to turning chemicals into biological organisms.

"We've made more progress on how the membrane of a protocell could grow and divide," Szostak said in a phone interview. "What we can do now is copy a limited set of simple [genetic] sequences, but we need to be able to copy arbitrary sequences so that sequences could evolve that do something useful."

By doing "something useful" for the cell, these genes would launch the new form of life down the Darwinian evolutionary path similar to the one that our oldest living ancestors must have traveled. Though where selective pressure will lead the new form of life is impossible to know.

"Once we can get a replicating environment, we're hoping to experimentally determine what can evolve under those conditions," said Sheref Mansy, a former member of Szostak's lab and now a chemi...

A sugar molecule linked to the origin of life was discovered in a potentially habitable region of our galaxy.

The molecule, called glycolaldehyde, was spotted in a large star-forming area of space around 26,000 light-years from Earth in the less-chaotic outer regions of the Milky Way. This suggests the sugar could be common across the universe, which is good news for extraterrestrial-life seekers.

"This is an important discovery as it is the first time glycolaldehyde, a basic sugar, has been detected towards a star-forming region where planets that could potentially harbor life may exist," Serena Viti of University College London said in a press release.

Previously, glycolaldehyde had only been observed toward the center of the galaxy, where conditions are thought to be too extreme to host habitable planets.

Glycolaldehyde is a key ingredient for life. It helps to build Ribonucleic acid (RNA), which is thought to be the central molecule involved in the origin of life on Earth. Glycolaldehyde is a monosaccharide sugar, the basic unit of carbohydrates. It can react with the chemical propenal to form ribose, the building block of RNA.

"The discovery of an organic sugar molecule in a star forming region of space is very exciting and will provide incredibly useful information in our search for alien life,” said Keith Mason, chief executive of the England’s Science and Technology Facilities Council.

The finding, made with the IRAM radio telescope in France, was announced Tuesday and will be published in the Astrophysical Journal Letters.

First detection of glycolaldehide outside the Galactic Center / arXiv:0811.3821v1

See Also:

• Biologists on the Verge of Creating New Form of Life
• Forgotten Experiment May Explain Origins of Life
• Life on Earth - and Other Planets - May Have Originated in Space